ECM and Cell Surface Proteolysis: Regulating Cellular Ecology
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ECM and Cell Surface Proteolysis: Regulating Cellular Ecology
Zena Werb mechanism could explain how the shedding of L-selec-tin and syndecan can occur within minutes upon cell Department of Anatomy University of California, San Francisco stimulation. Through these diverse mechanisms, adhesion , deadhesion, and ECM proteolysis are all brought San Francisco, California 94143-0750 to bear at the leading edge of migrating and invading cells where dynamic chan...
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Protein shedding, or the proteolytic cleavage of a protein from the surface of a cell, is emerging as an important mechanism in the regulation of cellular activity but it is poorly understood. Growing evidence suggesting that protein shedding and protein function are closely linked may lead to new strategies for the treatment of a wide range of diseases.
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Jé rô me Wuarin and Paul Nurse replication. Thus the control acting over S-phase onset Imperial Cancer Research Fund can be considered in two steps. The first, associated Cell Cycle Laboratory with the absence of CDK activity, makes the chromatin 44 Lincoln's Inn Fields permissive for DNA replication, and the second, associ-London WC2A 3PX UK ated with the presence of CDK activity, leads to the...
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Matriptase is an epithelial type II transmembrane serine protease with a complex modular structure and sophisticated activation mechanism. Reduced matriptase activity in mice or humans is associated with incomplete terminal differentiation of epidermis, epidermal appendages, oral epithelium, and, likely, other epithelial structures. Preliminary evidence indicates that matriptase is part of a se...
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BACKGROUND Branched actin assembly is critical for both cell motility and membrane trafficking. The branched actin regulator cortactin is generally considered to promote cell migration by controlling leading-edge lamellipodial dynamics. However, recent reports indicate that lamellipodia are not required for cell movement, suggesting an alternate mechanism. RESULTS Because cortactin also regul...
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ژورنال
عنوان ژورنال: Cell
سال: 1997
ISSN: 0092-8674
DOI: 10.1016/s0092-8674(00)80429-8